abstract：:As persons with Down's syndrome (DS) age into the third decade and beyond, they develop Alzheimer's disease (AD)-like histopathological changes in brain and may manifest progressive worsening of adaptive functions. Increasingly, persons with DS have near-normal to normal life spans; thus, it has become a therapeutic i...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Deutsch SI,Burket JA,Benson AD

更新日期：2014-10-03 00:00:00

abstract：:Phenelzine, a non-selective irreversible inhibitor of monoamine oxidase (MAO), has been used in the treatment of depression and anxiety disorders for several decades. It is a unique inhibitor of MAO as it is also a substrate for MAO, with one of the metabolites being β-phenylethylidenehydrazine (PEH), and it also inhi...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Matveychuk D,Nunes E,Ullah N,Aldawsari FS,Velázquez-Martínez CA,Baker GB

更新日期：2014-08-04 00:00:00

abstract：:Attention deficit hyperactivity disorder (ADHD) is a common and impairing disorder affecting millions of children, adolescents, and adults. Individuals with ADHD smoke cigarettes at rates significantly higher than their non-diagnosed peers and the disorder also confers risk for a number of related adverse smoking outc...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kollins SH,Adcock RA

更新日期：2014-07-03 00:00:00

abstract：:Cigarette smoking is the leading preventable cause of death in the Western world, with a considerably higher prevalence observed in schizophrenia compared to the general population. Despite the negative health consequences of smoking heavily, it has been proposed that individuals with schizophrenia may maintain smokin...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Mackowick KM,Barr MS,Wing VC,Rabin RA,Ouellet-Plamondon C,George TP

更新日期：2014-07-03 00:00:00

abstract：:Epilepsy is a neurological disorder with significant prevalence and the individuals affected by this disease have a great probability of occurrence of a lethal phenomenon known as Sudden Unexpected Death in Epilepsy (SUDEP). SUDEP occurs mainly during the night and probably during sleep. The pathophysiological mechani...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Matos G,Scorza FA,Mazzotti DR,Guindalini C,Cavalheiro EA,Tufik S,Andersen ML

更新日期：2014-06-03 00:00:00

abstract：:Previous observations of the pathophysiological distribution and pharmacological profile of the chemokine (C-C motif) ligand 2 (CCL2) have indicated its potential role in antipsychotic drug actions. More information on the pharmacogenetics of CCL2 may therefore be useful in developing individualized therapy. However, ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Xiong Y,Wei Z,Huo R,Wu X,Shen L,Li Y,Gong X,Wu Z,Feng G,Li W,He L,Xing Q,Qin S

更新日期：2014-06-03 00:00:00

abstract：:Neuropsychological endophenotype approach is an emerging strategy in schizophrenia research to understand and identify the functional importance of genetically transmitted, brain-based deficits present in this disorder. Accumulating evidence indicated that working memory deficit is a core neuropsychological dysfunctio...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Zhang C,Cai J,Zhang J,Li Z,Guo Z,Zhang X,Lu W,Zhang Y,Yuan A,Yu S,Fang Y

更新日期：2014-04-03 00:00:00

abstract：:Organic cation transporter 2 (OCT2) and 3 (OCT3) are low-affinity, high-capacity transporters (uptake-2) expressed in the central nervous system (CNS) and other major organs. Proven to be essential components in the CNS functions, OCT2 and OCT3 are suggested as potential targets of antidepressant therapeutics recently...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sun S,Wang K,Lei H,Li L,Tu M,Zeng S,Zhou H,Jiang H

更新日期：2014-03-03 00:00:00

abstract：INTRODUCTION:High-frequency repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) seemed to decrease tobacco consumption and craving in nicotine-dependent people without psychiatric disorder or otherwise healthy people. Even if the prevalence of cigarette smoking in sc...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Prikryl R,Ustohal L,Kucerova HP,Kasparek T,Jarkovsky J,Hublova V,Vrzalova M,Ceskova E

更新日期：2014-03-03 00:00:00

abstract：:Synaptic dysfunction has recently gained attention for its involvement in mood disorders. Electroconvulsive therapy (ECT) possibly plays a role in synaptic repair. However, the underlying mechanisms remain uncertain. Thrombospondin-1 (TSP-1), a member of the TSP family, is reported to be secreted by astrocytes and to ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Okada-Tsuchioka M,Segawa M,Kajitani N,Hisaoka-Nakashima K,Shibasaki C,Morinobu S,Takebayashi M

更新日期：2014-01-03 00:00:00

abstract：:Metformin is widely used to treat type II diabetes and other metabolic syndromes. In addition, it has been shown to increase neurogenesis, spatial memory formation and reduce the risk of Parkinson's disease. On this basis, the aim of the present study was the investigation of the protective potential of metformin in t...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Adedeji HA,Ishola IO,Adeyemi OO

更新日期：2014-01-03 00:00:00

abstract：OBJECTIVE:To investigate if cortisol alone or in interaction with other risk factors (familial risk, the serotonin transporter genotype, neuroticism and life events (LEs)) predicts onset of psychiatric disorder in healthy individuals at heritable risk. MATRIAL AND METHODS:In a high-risk study, 234 healthy monozygotic ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Vinberg M,Miskowiak K,Kessing LV

更新日期：2014-01-03 00:00:00

abstract：:Studies suggest that inflammation is involved in the neurodegenerative cascade of dementias. Immunological mechanisms may be part of the pathophysiological process in frontotemporal dementia (FTD), but up till now only vague evidence of such mechanisms has been presented. The B7- CD28/CTLA-4 pathway is an important im...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Santos RR,Torres KC,Lima GS,Fiamoncini CM,Mapa FC,Pereira PA,Rezende VB,Martins LC,Bicalho MA,Moraes EN,Reis HJ,Teixeira AL,Romano-Silva MA

更新日期：2014-01-03 00:00:00

abstract：:Previous studies have reported that selective serotonin reuptake inhibitors (SSRIs) may induce or exacerbate rapid eye movement (REM) sleep without atonia (RSWA) and increase the risk of developing REM sleep behavior disorder (RBD). However, most of these studies are retrospective and cross-sectional and employed smal...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Zhang B,Hao Y,Jia F,Tang Y,Li X,Liu W,Arnulf I

更新日期：2013-12-02 00:00:00

abstract：:There have been few attempts to integrate neurobiological and cognitive models of obsessive-compulsive disorder (OCD), although this might constitute a key approach to clarify the complex etiology of the disorder. Our study aimed to explore the neural correlates underlying dysfunctional beliefs hypothesized by cogniti...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Alonso P,Orbegozo A,Pujol J,López-Solà C,Fullana MÀ,Segalàs C,Real E,Subirà M,Martínez-Zalacaín I,Menchón JM,Harrison BJ,Cardoner N,Soriano-Mas C

更新日期：2013-12-02 00:00:00

abstract：:Depression is common among lung cancer patients. Increasing evidence has suggested that hypothalamic-pituitary-adrenal (HPA) axis and pro-inflammatory cytokines may play a key role in the pathophysiology of depression as well as cancer. This pilot study investigated the efficacy of sputum interleukin (IL)-6, tumor nec...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Du YJ,Zhang HY,Li B,Wu X,Lv YB,Jin HL,Cao YX,Sun J,Luo QL,Gong WY,Liu BJ,Wu JF,Shi SX,Dong JC

更新日期：2013-12-02 00:00:00

abstract：:Higher risk of dementia is expected for patients with late onset depression (LOD) history. The IL-10 polymorphisms are associated with Alzheimer disease (AD). On the other hand, there is no study associating IL-10 polymorphisms to LOD. This study aimed to investigate the -1082G/A polymorphism association in LOD, AD pa...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Torres KC,Araújo Pereira P,Lima GS,Bozzi IC,Rezende VB,Bicalho MA,Moraes EN,Miranda DM,Romano-Silva MA

更新日期：2013-12-02 00:00:00

abstract：:Exposure to surgery and general anesthesia (GA) has been hypothesized to be a potential risk factor for the development of Alzheimer's disease (AD). Some basic science research studies have demonstrated AD pathology in animals following exposure to inhalational anesthetics. However, controversy exists as to whether GA...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Seitz DP,Reimer CL,Siddiqui N

更新日期：2013-12-02 00:00:00

abstract：BACKGROUND:Previous studies concerning the association between the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and depression have provided inconclusive findings. A meta-analysis was therefore performed to investigate a more reliable estimate. METHODS:This meta-analysis recruited 26 publis...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wu YL,Ding XX,Sun YH,Yang HY,Chen J,Zhao X,Jiang YH,Lv XL,Wu ZQ

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Impaired mismatch negativity (MMN) is a robust finding in schizophrenia and, more recently, similar impairments have been reported in other psychotic- and affective-disorders (including at early stages of illness). Although cross-sectional studies have been numerous, there are few longitudinal studies that h...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kaur M,Lagopoulos J,Lee RS,Ward PB,Naismith SL,Hickie IB,Hermens DF

更新日期：2013-10-01 00:00:00

abstract：:A number of neuroprotective effects of curcumin have been demonstrated in recent years. However, whether curcumin exerts any beneficial effects on age-related impaired cognition and memory has not been well characterized; nor was there any detailed data on the molecular pathways activated by curcumin. The present stud...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Yu SY,Zhang M,Luo J,Zhang L,Shao Y,Li G

更新日期：2013-08-01 00:00:00

abstract：:A number of candidate gene studies focused on major depression (MD) and antidepressant (AD) efficacy have been carried out, but results mainly remain inconclusive. We performed a comprehensive meta-analysis of published candidate gene studies focused on AD efficacy in MD to evaluate the cumulative evidence. A random-e...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Niitsu T,Fabbri C,Bentini F,Serretti A

更新日期：2013-08-01 00:00:00

abstract：:The dynamics of most healthy physiological processes are complex, in that they are comprised of fluctuations with information-rich structure correlated over multiple temporospatial scales. Lipsitz and Goldberger (1992) first proposed that the aging process may be characterized by a progressive loss of physiologic comp...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Manor B,Lipsitz LA

更新日期：2013-08-01 00:00:00

abstract：:Extensive studies showed that monoaminergic neurotransmission that involves serotonin (5-HT), norepinephrine (NE) and dopamine (DA) exerts major influence on brain circuits concerned by the regulation of mood, reactivity to psychological stress, self-control, motivation, drive, and cognitive performance. Antidepressan...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Hamon M,Blier P

更新日期：2013-08-01 00:00:00

abstract：:Chronic amphetamine use results in anxiety-like states after drug cessation. The aim of the study was to determine a role of ionotropic and metabotropic glutamate receptor ligands in amphetamine-evoked withdrawal anxiety in the elevated plus-maze test in rats. In our study memantine (8 and 12 mg/kg), a noncompetitive ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Koltunowska D,Gibula-Bruzda E,Kotlinska JH

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Neurological soft signs (NSS) are minor neurological abnormalities, including motor, sensory, and inhibitory dysfunction. Schizophrenia and other neuropsychiatric disorders are associated with a higher prevalence of NSS. However, the relationships between NSS and schizophrenia, bipolar disorder, and major de...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Zhao Q,Ma YT,Lui SS,Liu WH,Xu T,Yu X,Tan SP,Wang ZR,Qu M,Wang Y,Huang J,Cheung EF,Dazzan P,Chan RC

更新日期：2013-06-03 00:00:00

abstract：:While it is now well established that the independent brain renin-angiotensin system (RAS) has some important central functions besides the vascular ones, the relevance of its main bioactive peptide angiotensin II (Ang II) on the memory processes, as well as on oxidative stress status is not completely understood. The...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Bild W,Hritcu L,Stefanescu C,Ciobica A

更新日期：2013-06-03 00:00:00

abstract：:The symptoms of psychosis and mania are both related to dopaminergic hyperactivity. In psychosis, it is proposed that post-synaptic receptor sensitization causes dysfunctional salience processing, leading to the development of delusional symptoms. In various animal models of psychosis, the mechanism of post-synaptic s...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Park SY,Kang UG

更新日期：2013-06-03 00:00:00

abstract：:Mecamylamine, a noncompetitive antagonist of nicotinic acetylcholine receptors, has many potential clinical applications, including treating alcohol dependency. However, little is known about the combined effects of mecamylamine and alcohol on visual system electrophysiology. We examined the separate and combined effe...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Hetzler BE,Bauer AM

更新日期：2013-06-03 00:00:00

abstract：:Antipsychotics, which act predominantly as dopamine D2 receptor antagonists, have several shortcomings. The exact pathophysiological mechanism leading to dopaminergic dysfunction in schizophrenia is still unclear, but inflammation has been postulated to be a key player in the pathophysiology of the disorder. A dysfunc...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Müller N,Myint AM,Krause D,Weidinger E,Schwarz MJ

更新日期：2013-04-05 00:00:00

abstract：OBJECTIVE:Bipolar disorder patients experiencing a depressive episode (BD-dep) without an observed history of mania are often misdiagnosed and are consequently treated as having unipolar depression (UD), leading to inadequate treatment and poor outcomes. An essential solution to this problem is to identify objective bi...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Liu CH,Ma X,Wu X,Zhang Y,Zhou FC,Li F,Tie CL,Dong J,Wang YJ,Yang Z,Wang CY

更新日期：2013-03-05 00:00:00

abstract：INTRODUCTION:The dopamine D4 receptor (DRD4) is a promising candidate gene in obsessive compulsive disorder (OCD). A 48-bp variable number of tandem repeats (VNTR) sequence in exon 3 has been studied previously, and alleles containing 2-11 repeats (2R-11R) have been identified. We investigated the association of DRD4 V...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Taj M J RJ,Viswanath B,Purushottam M,Kandavel T,Janardhan Reddy YC,Jain S

更新日期：2013-03-05 00:00:00

abstract：OBJECTIVE:The Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) is a key measure of social cognition in schizophrenia that has good psychometric properties and is recommended by the MATRICS committee. As a way to further investigate the validity of the MSCEIT, this study sought to examine the neurobiological co...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wojtalik JA,Eack SM,Keshavan MS

更新日期：2013-01-10 00:00:00

abstract：BACKGROUND:The aims of the present study were to examine the association between a common serotonin transporter gene (SLC6A4) polymorphism 5-HTTLPR/rs25531 with severity of attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) symptoms. METHODS:Mothers and teachers completed a validated DS...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Gadow KD,DeVincent CJ,Siegal VI,Olvet DM,Kibria S,Kirsch SF,Hatchwell E

更新日期：2013-01-10 00:00:00

abstract：:Following chronic administration of morphine a locomotor sensitization is usually observed. This behavioral sensitization is influenced by numerous factors including the administration pattern. While methadone and buprenorphine are the two main treatments for opioid dependence, literature about their ability to promot...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Allouche S,Le Marec T,Noble F,Marie N

更新日期：2013-01-10 00:00:00

abstract：:The aim of the current study was to examine the existence of a cooperative interaction between the basolateral nucleus of amygdala (BLA) and the ventral tegmental area (VTA) in inhibitory avoidance task. The BLA and the VTA regions of adult male Wistar rats were simultaneously cannulated and memory consolidation was m...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Nazari-Serenjeh F,Rezayof A

更新日期：2013-01-10 00:00:00

abstract：:Metabotropic glutamate receptors (mGlu) have been implicated in the regulation of physiological and behavioral processes. Pharmacological evidence involves group I mGlu receptors in the regulation of emotional states and antagonism of these receptors has been proposed as a novel class of anxiolytic drugs having also a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Cavas M,Scesa G,Navarro JF

更新日期：2013-01-10 00:00:00

abstract：:Recent studies have revealed that aberrant vitamin A signaling may lead to memory deficits in rodents. Present study investigates the potential of all-trans-retinoic acid (ATRA) an agonist at retinoid acid family of receptors, in cognitive dysfunctions associated with experimental dementia. Streptozotocin (STZ) [3 mg/...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sodhi RK,Singh N

更新日期：2013-01-10 00:00:00

abstract：:Treatment of the positive psychotic symptoms of schizophrenia with standard antipsychotic drugs (APDs) is ineffective in a proportion of cases. For these treatment resistant patients the alternative is the APD clozapine which is superior to other agents but carries serious side effects. Why clozapine is uniquely effec...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pereira A,Zhang B,Malcolm P,Sundram S

更新日期：2013-01-10 00:00:00

abstract：:Endogenous cannabinoid ligands and cannabinoid CB1 receptor agonists have been shown to exert anticonvulsant effects in various experimental models of epilepsy. The purpose of this study was to determine the effects of arachidonyl-2'-chloroethylamide (ACEA-a highly selective cannabinoid CB1 receptor agonist) on the pr...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Andres-Mach M,Zolkowska D,Barcicka-Klosowska B,Haratym-Maj A,Florek-Luszczki M,Luszczki JJ

更新日期：2012-12-03 00:00:00